98139-72-1 Usage
Uses
Used in Chemical Synthesis:
3-METHYL-1-BUTYLBORONIC ACID is used as a reactant for selective copper-promoted cross-coupling with aromatic amines. This reaction is crucial for the synthesis of various organic compounds and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-METHYL-1-BUTYLBORONIC ACID is used as a reactant for the synthesis of indazole-based analogs that are sensitive Akt inhibitors. These inhibitors play a significant role in the development of drugs targeting various diseases, including cancer.
Used in Organic Chemistry Research:
3-METHYL-1-BUTYLBORONIC ACID is also used in the preparation of alkylarenes via tetraphosphine-palladium-catalyzed Suzuki cross-coupling with aryl halides. This method is essential for the synthesis of complex organic molecules and the development of new materials and compounds in organic chemistry research.
Check Digit Verification of cas no
The CAS Registry Mumber 98139-72-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,1,3 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 98139-72:
(7*9)+(6*8)+(5*1)+(4*3)+(3*9)+(2*7)+(1*2)=171
171 % 10 = 1
So 98139-72-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H13BO2/c1-5(2)3-4-6(7)8/h5,7-8H,3-4H2,1-2H3
98139-72-1Relevant academic research and scientific papers
P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease
Priestley,De Lucca, Indawati,Ghavimi, Bahman,Erickson-Viitanen, Susan,Decicco, Carl P.
, p. 3199 - 3202 (2007/10/03)
A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p-trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.
