914299-15-3 Usage
Uses
Used in Pharmaceutical Synthesis:
N-Boc-3-methyl-4-pyrrolidin-2-ylbenzoic acid methyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of potential drug candidates. The Boc group's presence facilitates the synthesis process by protecting the carboxylic acid, which can be removed under mild conditions to yield the desired free carboxylic acid functionality.
Used in Agrochemical Development:
In the agrochemical industry, N-Boc-3-methyl-4-pyrrolidin-2-ylbenzoic acid methyl ester is utilized as a building block for the creation of new chemical entities with pesticidal properties. Its protected carboxylic acid group allows for the development of compounds that can be further modified to target specific pests or diseases in agriculture.
Used in Organic Synthesis Research:
As a versatile intermediate, N-Boc-3-methyl-4-pyrrolidin-2-ylbenzoic acid methyl ester is also used in academic and industrial research for organic synthesis. Its protected functional group makes it a valuable tool for exploring new synthetic pathways and developing innovative methodologies in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 914299-15-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,2,9 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 914299-15:
(8*9)+(7*1)+(6*4)+(5*2)+(4*9)+(3*9)+(2*1)+(1*5)=183
183 % 10 = 3
So 914299-15-3 is a valid CAS Registry Number.
914299-15-3Relevant academic research and scientific papers
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
Kung, Pei-Pei,Funk, Lee,Meng, Jerry,Collins, Michael,Zhou, Joe Zhongxiang,Catherine Johnson,Ekker, Anne,Wang, Jeff,Mehta, Pramod,Yin, Min-Jean,Rodgers, Caroline,Davies II, Jay F.,Bayman, Eileen,Smeal, Tod,Maegley, Karen A.,Gehring, Michael R.
scheme or table, p. 6273 - 6278 (2009/08/15)
Information from X-ray crystal structures were used to optimize the potency of a HTS hit in a Hsp90 competitive binding assay. A class of novel and potent small molecule Hsp90 inhibitors were thereby identified. Enantio-pure compounds 31 and 33 were potent in PGA-based competitive binding assay and inhibited proliferation of various human cancer cell lines in vitro, with IC50 values averaging 20 nM.
AMIDE RESORCINOL COMPOUNDS
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Page/Page column 76-77, (2008/12/05)
The present invention is directed to amide resorcinol compounds and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.
AMIDE RESORCINOL COMPOUNDS
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Page/Page column 40; 105, (2008/06/13)
The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.
