914347-48-1 Usage
General Description
2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL, also known as methotrexate, is a chemical compound with potential antineoplastic and immunosuppressant activities. It is a folate antagonist that acts by inhibiting the enzyme dihydrofolate reductase, resulting in the depletion of reduced folates and the inhibition of purine and thymidylate synthesis necessary for DNA replication. 2-[4-(6-AMINO-2-METHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]ETHANOL is commonly used as a chemotherapy agent for the treatment of various types of cancer, including leukemia, lymphoma, and breast cancer, as well as for the management of autoimmune diseases such as rheumatoid arthritis and psoriasis. Additionally, it has been studied for its potential in the treatment of ectopic pregnancy and severe inflammatory bowel disease.
Check Digit Verification of cas no
The CAS Registry Mumber 914347-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,3,4 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 914347-48:
(8*9)+(7*1)+(6*4)+(5*3)+(4*4)+(3*7)+(2*4)+(1*8)=171
171 % 10 = 1
So 914347-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H19N5O/c1-9-13-10(12)8-11(14-9)16-4-2-15(3-5-16)6-7-17/h8,17H,2-7H2,1H3,(H2,12,13,14)
914347-48-1Relevant articles and documents
ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS
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, (2021/10/15)
Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).
MULTIPLE KINASE PATHWAY INHIBITORS
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, (2014/04/17)
Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.
