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Usage

Uses

Used in Organic Synthesis:
1-Boc-5-benzyloxy-3-formylindole is used as a building block in organic synthesis for the creation of a variety of biologically active molecules. Its unique structure allows for the formation of complex organic compounds that can exhibit a range of pharmacological properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-Boc-5-benzyloxy-3-formylindole is employed as a key intermediate in the synthesis of pharmaceuticals. Its presence in the molecular structure can contribute to the development of drugs with novel mechanisms of action and therapeutic potential.
Used in Antiviral Research:
1-Boc-5-benzyloxy-3-formylindole is used as a potential antiviral agent in research. Its unique chemical structure may offer new avenues for the development of antiviral drugs, particularly against viruses that are resistant to existing treatments.
Used in Antibacterial Research:
Similarly, in antibacterial research, 1-Boc-5-benzyloxy-3-formylindole is utilized to explore its potential as an antibacterial agent. 1-Boc-5-benzyloxy-3-formylindole may contribute to the discovery of new antibiotics to combat antibiotic-resistant bacteria.
Used in Drug Discovery:
1-Boc-5-benzyloxy-3-formylindole is employed in drug discovery efforts as a promising candidate for the development of new pharmaceuticals. Its diverse applications in medicinal chemistry and potential pharmacological activity make it a valuable tool in the search for innovative treatments for various diseases and conditions.

Upstream product

• 1953-54-4 indol-5-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6953-22-6 5-benzyloxyindole-3-carboxaldehyde 
• 1215-59-4 5-benzyloxy-1H-indole 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Structure-guided design, synthesis, and biological evaluation of (2-(1 H-Indol-3-yl)-1 H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) methanone (ABI-231) analogues targeting the colchicine binding site in Tubulin

ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. Guided by the crystal structure of ABI-231 in complex with tubulin, we performed structure-activity relationship studies around the 3-indole moiety that led to the discovery of several potent ABI-231 analogues, most notably 10ab and 10bb. The crystal structures of 10ab and 10bb in complex with tubulin confirmed their improved molecular interactions to the colchicine site. In vitro, biological studies showed that new ABI-231 analogues disrupt tubulin polymerization, promote microtubule fragmentation, and inhibit cancer cell migration. In vivo, analogue 10bb not only significantly inhibits primary tumor growth and decreases tumor metastasis in melanoma xenograft models but also shows a significant ability to overcome paclitaxel resistance in a taxane-resistant PC-3/TxR model. In addition, pharmacological screening suggested that 10bb has a low risk of potential off-target function.

C4 Pictet-Spengler Reactions for the Synthesis of Core Structures in Hyrtiazepine Alkaloids

The hyrtiazepine alkaloids are a family of bisindole natural products that have the azepinoindole backbone. We developed a biomimetic approach by constructing the azepinoindole core in a one-pot manner through 1,4-diazabicyclo[2.2.2]octane/2,2,2-trifluoroethanol (DABCO/TFE) promoted Pictet-Spengler reaction onto the C-4 position of tryptophan. This strategy allowed the synthesis of common key structures of these families. The key intermediate can be converted into the 3 H -pyrano[2,3- b:5,6- e ′]diindol intermediate present in hyrtimomines A and B, as well as the azepinoindole core present in fargesine..