914348-99-5 Usage
Uses
Used in Pharmaceutical Industry:
1-Boc-7-benzyloxy-3-formylindole is used as a key intermediate in the synthesis of pharmaceutical compounds for its unique structure and reactivity. The Boc group allows for selective reactions, facilitating the creation of complex molecules with specific therapeutic properties.
Used in Organic Chemistry Research:
In the field of organic chemistry, 1-Boc-7-benzyloxy-3-formylindole serves as a valuable research tool for exploring novel synthetic pathways and developing new methodologies. Its reactivity and structural features make it an ideal candidate for studying various chemical reactions and mechanisms.
Used in the Synthesis of Complex Molecules:
1-Boc-7-benzyloxy-3-formylindole is employed as a building block in the assembly of complex organic molecules, such as natural products, pharmaceuticals, and other bioactive compounds. Its unique functional groups and protective Boc group enable the construction of intricate molecular architectures with desired properties.
Used in Drug Development:
In drug development, 1-Boc-7-benzyloxy-3-formylindole is utilized as a precursor in the synthesis of potential drug candidates. Its versatility in chemical reactions allows for the generation of diverse molecular structures with potential therapeutic effects.
Overall, 1-Boc-7-benzyloxy-3-formylindole is a versatile and valuable compound in the fields of organic chemistry and pharmaceuticals, with a wide range of applications in the synthesis of complex molecules and the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 914348-99-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,3,4 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 914348-99:
(8*9)+(7*1)+(6*4)+(5*3)+(4*4)+(3*8)+(2*9)+(1*9)=185
185 % 10 = 5
So 914348-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H21NO4/c1-21(2,3)26-20(24)22-12-16(13-23)17-10-7-11-18(19(17)22)25-14-15-8-5-4-6-9-15/h4-13H,14H2,1-3H3
914348-99-5Relevant academic research and scientific papers
Structure-guided design, synthesis, and biological evaluation of (2-(1 H-Indol-3-yl)-1 H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) methanone (ABI-231) analogues targeting the colchicine binding site in Tubulin
Wang, Qinghui,Arnst, Kinsie E.,Wang, Yuxi,Kumar, Gyanendra,Ma, Dejian,White, Stephen W.,Miller, Duane D.,Li, Wei,Li, Weimin
, p. 6734 - 6750 (2019/08/20)
ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. Guided by the crystal structure of ABI-231 in complex with tubulin, we performed structure-activity relationship studies around the 3-indole moiety that led to the discovery of several potent ABI-231 analogues, most notably 10ab and 10bb. The crystal structures of 10ab and 10bb in complex with tubulin confirmed their improved molecular interactions to the colchicine site. In vitro, biological studies showed that new ABI-231 analogues disrupt tubulin polymerization, promote microtubule fragmentation, and inhibit cancer cell migration. In vivo, analogue 10bb not only significantly inhibits primary tumor growth and decreases tumor metastasis in melanoma xenograft models but also shows a significant ability to overcome paclitaxel resistance in a taxane-resistant PC-3/TxR model. In addition, pharmacological screening suggested that 10bb has a low risk of potential off-target function.
