914360-82-0

Basic information

• Product Name: ethyl 2-(3-chloropyrazin-2-yl)acetate
• Synonyms: ethyl 2-(3-chloropyrazin-2-yl)acetate
• CAS NO: 914360-82-0
• Molecular Weight: 200.625
• Mol File: 914360-82-0.mol

Chemical Properties

• Boiling Point: 268.8±35.0 °C(Predicted)
• Density: 1.276±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl 2-(3-chloropyrazin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3-chloropyrazin-2-yl)acetate(914360-82-0)
• EPA Substance Registry System: ethyl 2-(3-chloropyrazin-2-yl)acetate(914360-82-0)

Safety Data

• Hazardous Substances Data: 914360-82-0(Hazardous Substances Data)

Upstream product

• 4858-85-9 2,3-dichloropyrazine 
• 141-78-6 ethyl acetate 
• 259673-42-2 diethyl 2-(3-chloropyrazin-2-yl)propanedioate 
• 64-17-5 ethanol 
• 1260787-77-6 2-(3-chloropyrazin-2-yl)acetic acid 

Downstream Products

• 940933-31-3 5-(4-chlorophenyl)-4-(3-chloro-2-pyrazyl)-6-methyl-2H-pyridazin-3-one 
• 940933-12-0 3-chloro-5-(4-chlorophenyl)-4-(3-chloro-2-pyrazinyl)-6-methylpyridazine 
• 1393900-65-6 2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide 
• 1393900-64-5 2-(3-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide 
• 1393901-55-7 tert-butyl 4-(4-((4-(2-(3-(2-amino-2-oxoethyl)pyrazin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-54-6 tert-butyl 4-(4-((4-(2-(3-(2-ethoxy-2-oxoethyl)pyrazin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-53-5 tert-butyl 4-(4-((4-((3-(2-ethoxy-2-oxoethyl)pyrazin-2-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 

Relevant articles and documents

Diversity-oriented synthesis of bicyclic fragments containing privileged azines

An innovative and efficient reagent- and scaffold-based diversity oriented synthesis (DOS) of a fragment set was developed for fragment-based drug discovery (FBDD) programs. Twelve diverse, functionalized and bicyclic scaffolds were rapidly accessed by adopting a convenient synthetic toolkit around three privileged azine cores in order to effectively modulate biomolecules. These structures are characterized by both key motifs for interacting with diverse biological targets via hydrogen bonds and useful points of growth for subsequent fragment optimization.

HERBICIDAL COMPOUNDS

The present invention relates to herbicidal benzyloxy-substituted phenyl diones and benzyloxy-substituted phenyl-dioxo-thiazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The inven

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

HERBICIDAL COMPOUNDS

The present invention provides a compound of formula (I) wherein R4 is of sub-formula (a) or (b) and wherein the other substituents are as defined in the specification. The compounds of formula (I) are potentially useful as herbicides.

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.

PYRIDAZINE COMPOUND AND USE THEREOF

A pyridazine compound of the formula: has an excellent plant disease controlling effect.

Highly selective substitutions in 2,3-dichloropyrazine. A novel general approach to aloisines

A highly efficient synthesis of the potent CDKs (cyclin-dependent kinases) inhibitors, aloisines (substituted 5H-pyrrolo[2,3-b]pyrazines) is presented. The method is based on highly selective monosubstitution of a single chlorine atom in 2,3-dichloropyraz