914380-18-0

Basic information

• Product Name: N-benzyl-N-((3-(4-phenylpiperazin-1-yl)propylcarbamoyl)methyl)aminoacetic acid
• CAS NO: 914380-18-0
• Molecular Weight: 424.543
• Mol File: 914380-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-((3-(4-phenylpiperazin-1-yl)propylcarbamoyl)methyl)aminoacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-((3-(4-phenylpiperazin-1-yl)propylcarbamoyl)methyl)aminoacetic acid(914380-18-0)
• EPA Substance Registry System: N-benzyl-N-((3-(4-phenylpiperazin-1-yl)propylcarbamoyl)methyl)aminoacetic acid(914380-18-0)

Safety Data

• Hazardous Substances Data: 914380-18-0(Hazardous Substances Data)

Upstream product

• 20529-19-5 3-(4-phenylpiperazin-1-yl)propan-1-amine 
• 25557-30-6 2-[3-(4-penylpiperazin-1-yl)propyl]-1H-isoindole-1,3(2H)-dione 
• 92-54-6 4-phenyl-1-piperazine 

Relevant articles and documents

Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors

As the matrix metalloproteinases (MMPs) can be massively up-regulated in degenerative tissues and degrade the extracellular matrix, these key enzymes are promising targets for the therapy of cancer and other degenerative diseases. Here, we are presenting a series of new non-peptidic hydroxamate-based matrix metalloproteinase inhibitors, MMPIs, incorporating the iminodiacetic (IDA) hydroxamic acid scaffold, as mimics of truncated peptidic MMPIs. A series of alkylaryl and sulfonylaryl groups, on the IDA basic scaffold, was investigated with the aim of improving potency and selectivity against MMPs involved in degenerative diseases. The sulfonamide based IDA derivatives studied (compounds B1-B3) showed to be potent (nM range) against deep S1′ pocket MMPs enzymes (i.e., MMP-2).