914398-46-2Relevant academic research and scientific papers
N-spiro chiral quaternary ammonium bromide catalyzed diastereo- and enantioselective conjugate addition of nitroalkanes to cyclic α,β-unsaturated ketones under phase-transfer conditions
Ooi, Takashi,Takada, Saki,Fujioka, Shingo,Maruoka, Keiji
, p. 5143 - 5146 (2005)
(Chemical Equation Presented) Conjugate addition of various prochiral nitroalkanes to cyclic α,β-unsaturated ketones was found to be efficiently catalyzed by N-spiro C2-symmetric chiral quaternary ammonium bromide 1b possessing a 3,5-bis(3,4,5-
Asymmetric Michael addition of silyl nitronates to cyclic α,β-unsaturated ketones catalyzed by chiral quaternary ammonium bifluorides: Isolation and selective functionalization of enol silyl ethers of optically active γ-nitro ketones
Ooi, Takashi,Doda, Kanae,Takada, Saki,Maruoka, Keiji
, p. 145 - 148 (2006)
Highly enantioselective Michael addition of silyl nitronates to cyclic α,β-unsaturated ketones has been accomplished by the utilization of N-spiro C2-symmetric chiral quaternary ammonium bifluoride 1 as an efficient catalyst, offering a new rou
A versatile approach to functionalized cyclic ketones bearing quaternary carbon stereocenters via organocatalytic asymmetric conjugate addition of nitroalkanes to cyclic β-substituted α,β-Enones
Yu, Si-Jia,Zhu, Ya-Nan,Ye, Jian-Liang,Huang, Pei-Qiang
, (2021/03/01)
A versatile organocatalytic asymmetric conjugate addition of nitroalkanes to β-substituted cyclic α,β-enones to yield cyclic ketones bearing all-carbon quaternary stereogenic centers at β-C has been developed. This is an extension of the method that we de
Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics
Hanessian, Stephen,Maji, Dilip K.,Govindan, Subramaniyan,Matera, Riccardo,Tintelnot-Blomley, Marina
experimental part, p. 2861 - 2876 (2010/07/17)
The asymmetric synthesis of a carbocyclic Δ-amino acid representing the P2/P3 subunit of a nonpeptidic truncated peptidomimetic molecule is described relying on two independent approaches.
Asymmetric conjugate addition of nitroalkanes to enones with a chiral α-aminophosphonate catalyst
Malmgren, Marcus,Granander, Johan,Amedjkouh, Mohamed
, p. 1934 - 1940 (2008/12/22)
Chiral diethyl (2R)-tetrahydropyrro-2-ylphosphonate is an effective catalyst for the Michael addition of nitroalkanes to α,β-unsaturated ketones. This study revealed that the hydrate salt of this α-aminophosphonate was found to be a better catalytic speci
Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline
Hanessian, Stephen,Shao, Zhihui,Warrier, Jayakumar S.
, p. 4787 - 4790 (2007/10/03)
(Chemical Equation Presented) The conjugate addition of symmetrical 2-nitroalkanes to 2-cycloalkenones catalyzed by trans-4,5-methano-L-proline proceeds with >99% ee and excellent chemical yields. 1-Nitroalkanes afford diastereomeric syn/anti products tha
