91448-08-7

Basic information

• Product Name: 3-Hydroxy-4-carboxy-benzoldiazonium-chlorid
• CAS NO: 91448-08-7
• Molecular Weight: 200.581
• Mol File: 91448-08-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Hydroxy-4-carboxy-benzoldiazonium-chlorid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-4-carboxy-benzoldiazonium-chlorid(91448-08-7)
• EPA Substance Registry System: 3-Hydroxy-4-carboxy-benzoldiazonium-chlorid(91448-08-7)

Safety Data

• Hazardous Substances Data: 91448-08-7(Hazardous Substances Data)

Upstream product

• 65-49-6 4-Aminosalicylic acid 

Downstream Products

• 111329-52-3 2,2'-dihydroxy-4,4'-m-phenylenedisulfamoyl-di-benzoic acid 
• 111329-53-4 1,4-bis-(4-carboxy-3-hydroxy-benzenesulfonylamino)-benzene 
• 107625-11-6 2-hydroxy-4-phenylsulfamoyl-benzoic acid 
• 43059-24-1 2-hydroxy-4-sulfamoyl-benzoic acid 
• 98273-15-5 4-chlorosulfonyl-2-hydroxy-benzoic acid 

Relevant articles and documents

Hydrodabcyl: A Superior Hydrophilic Alternative to the Dark Fluorescence Quencher Dabcyl

Dark fluorescence quenchers are nonfluorescent dyes that can modulate the fluorescence signal of an appropriate fluorophore donor in a distance-dependent manner. Dark quenchers are extensively used in many biomolecular analytical applications, such as studies with fluorogenic protease substrates or nucleic acids probes. A very popular dark fluorescence quencher is dabcyl, which is a hydrophobic azobenzene derivative. However, its insolubility in water may constitute a major drawback, especially during the investigation of biochemical systems whose natural solvent is water. We designed and synthesized a new azobenzene-based dark quencher with excellent solubility in aqueous media, which represents a superior alternative to the much-used dabcyl. The advantage of hydrodabcyl over dabcyl is exemplarily demonstrated for the cleavage of the fluorogenic substrate hydrodabcyl-Ser-Phe-EDANS by the proteases thermolysin and papain.