914490-41-8

Basic information

• Product Name: (S)-2-amino-4-bromo-butyric acid benzyl ester hydrochloride
• Synonyms: (S)-2-amino-4-bromo-butyric acid benzyl ester hydrochloride
• CAS NO: 914490-41-8
• Molecular Weight: 308.603
• Mol File: 914490-41-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-amino-4-bromo-butyric acid benzyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-4-bromo-butyric acid benzyl ester hydrochloride(914490-41-8)
• EPA Substance Registry System: (S)-2-amino-4-bromo-butyric acid benzyl ester hydrochloride(914490-41-8)

Safety Data

• Hazardous Substances Data: 914490-41-8(Hazardous Substances Data)

Upstream product

• 15159-65-6 (2S)-2-amino-4-bromobutanoic acid hydrobromide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 95656-97-6 benzyl 4-bromo-2-<(tert-butyloxy)carbonylamino>butanoate 

Relevant articles and documents

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.