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15159-65-6

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15159-65-6 Usage

Chemical Properties

white to light beige powder

Uses

(S)-(+)-2-Amino-4-bromobutyric acid hydrobromide may be used in the synthesis of metalloaminoacids such as [34S]-enriched methionine (34S-Met), telluromethionine (TeMet) and selenohomolanthionine (SeHLan).

Check Digit Verification of cas no

The CAS Registry Mumber 15159-65-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,5 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 15159-65:
(7*1)+(6*5)+(5*1)+(4*5)+(3*9)+(2*6)+(1*5)=106
106 % 10 = 6
So 15159-65-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H8BrNO2.BrH/c5-2-1-3(6)4(7)8;/h3H,1-2,6H2,(H,7,8);1H/t3-;/m0./s1

15159-65-6 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (A1450)  (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide  >98.0%(N)(T)

  • 15159-65-6

  • 1g

  • 860.00CNY

  • Detail
  • TCI America

  • (A1450)  (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide  >98.0%(N)(T)

  • 15159-65-6

  • 5g

  • 2,990.00CNY

  • Detail
  • Aldrich

  • (476986)  (S)-(+)-2-Amino-4-bromobutyricacidhydrobromide  97%

  • 15159-65-6

  • 476986-1G

  • 1,151.28CNY

  • Detail

15159-65-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-(+)-2-Amino-4-bromobutyric acid hydrobromide

1.2 Other means of identification

Product number -
Other names (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15159-65-6 SDS

15159-65-6Relevant articles and documents

Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents

Almaliti, Jehad,Miller, Bailey,Pietraszkiewicz, Halina,Glukhov, Evgenia,Naman, C. Benjamin,Kline, Toni,Hanson, Jeffrey,Li, Xiaofan,Zhou, Sihong,Valeriote, Frederick A.,Gerwick, William H.

, p. 416 - 432 (2018/10/31)

Antibody–drug conjugates (ADCs) represent a new dimension of anticancer chemotherapeutics, with warheads to date generally involving either antitubulin or DNA-directed agents to achieve low-to sub-nanomolar potency. However, other potent cytotoxins working by different pharmacological mechanisms are under investigation, such as α,β-epoxyketone based proteasome inhibitors. These proteasome active agents are an emerging class of anticancer drug that possesses ultra-potent cytotoxicity to some cancer cell lines. The carmaphycins are representatives of this latter class that we isolated and characterized from a marine cyanobacterium, and these as well as several synthetic analogues exhibit this level of potency. In the current work, we investigated the use of these highly potent cytotoxic compounds as warheads in the design of novel ADCs. We designed and synthesized a library of carmaphycin B analogues that contain amine handles, enabling their attachment to an antibody linker. The basicity of these incorporated amine handles was shown to strongly affect their cytotoxic properties. Linear amines resulted in the greatest reduction in cytotoxicity whereas less basic aromatic amines retained potent activity as demonstrated by a 4-sulfonylaniline derivative. These investigations resulted in identifying the P2 residue in the carmaphycins as the most suitable site for linker attachment point, and hence, we synthesized a highly potent analogue of carmaphycin B that contained a 4-sulfonylaniline handle as an attachment point for the linker antibody.

Enantiopure azetidine-2-carboxamides as organocatalysts for direct asymmetric aldol reactions in aqueous and organic media

Song, Xixi,Liu, Ai-Xiang,Liu, Shan-Shan,Gao, Wen-Chao,Wang, Min-Can,Chang, Junbiao

, p. 1464 - 1470 (2014/02/14)

A family of enantiopure azetidine-2-caboxamides was asymmetrically synthesized, and was examined as organocatalyst in direct aldol reactions. A well chosen chiral azetidine-2-caboxamide was found to smoothly catalyze the direct aldol reaction of various benzaldehydes with acetone in brine, and β-hydroxy ketones were produced with enantiomeric excess up to 96%. The reaction of benzaldehydes with cyclic ketones also led to the formation of anti-products in diastereomeric ratio up to 99:1 and enantiomeric excess up to 99%.

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease

Jiang, Yutong,Andrews, Steven W.,Condroski, Kevin R.,Buckman, Brad,Serebryany, Vlad,Wenglowsky, Steve,Kennedy, April L.,Madduru, Machender R.,Wang, Bin,Lyon, Michael,Doherty, George A.,Woodard, Benjamin T.,Lemieux, Christine,Do, Mary Geck,Zhang, Hailong,Ballard, Joshua,Vigers, Guy,Brandhuber, Barbra J.,Stengel, Peter,Josey, John A.,Beigelman, Leonid,Blatt, Lawrence,Seiwert, Scott D.

supporting information, p. 1753 - 1769 (2014/04/03)

HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human innate im

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