914613-35-7 Usage
Chemical Properties
White Solid
Uses
Candesartan Cilexetil Impurity E (PHARMEUROPA).
Biological Activity
1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].
references
[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38. [2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.
Check Digit Verification of cas no
The CAS Registry Mumber 914613-35-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,6,1 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 914613-35:
(8*9)+(7*1)+(6*4)+(5*6)+(4*1)+(3*3)+(2*3)+(1*5)=157
157 % 10 = 7
So 914613-35-7 is a valid CAS Registry Number.
914613-35-7Relevant articles and documents
Identification, synthesis and structural determination of some impurities of candesartan cilexetil
Havllcek, Jaroslav,Mandelova, Zuzana,Weisemann, Ruediger,Strelec, Ivo,Placek, Lukas,Radl, Stanislav
experimental part, p. 347 - 362 (2009/06/28)
All principal candesartan cilexetil impurities and/or degradation products were synthesized and identified. The differentiation of N-l and N-2 ethylated candesartan cilexetil derivatives was performed using ID and 2D NMR experiments. The influence of the magnetic field on the resolution and sensitivity of NMR experiments is shown. Selective hydrolysis of these compounds then provided corresponding producrs of hydrolysis of the ethoxy group. Institute of Organic Chemistry and Biochemistry.
