914616-06-1Relevant articles and documents
Preparation of optically active (2RS,3SR)-2-amino-3-hydroxy-3- phenylpropanoic acid (threo-β-phenylserine) via optical resolutions by replacing and preferential crystallization
Shiraiwa, Tadashi,Kawashima, Yuka,Ikaritani, Atsushi,Suganuma, Yumiko,Saijoh, Reiichi
, p. 1170 - 1174 (2006)
To obtain optically active threo-2-amino-3-hydroxy-3-phenylpropanoic acid (1) via optical resolutions by replacing and preferential crystallization, the racemic structure of (2RS,3SR)-1 hydrochloride [(2RS,3SR)-1·HCl] was examined based on the melting poi
Gymnangiamide, a Cytotoxic Pentapeptide from the Marine Hydroid Gymnangium regae
Milanowski, Dennis J.,Gustafson, Kirk R.,Rashid, Mohammad A.,Pannell, Lewis K.,McMahon, James B.,Boyd, Michael R.
, p. 3036 - 3042 (2007/10/03)
A cytotoxic aqueous extract from the marine hydroid Gymnangium regae provided a novel linear pentapeptide, designated gymnangiamide (1). The planar structure of 1 was elucidated by interpretation of spectral data as well as chemical degradation and derivatization studies. In addition to the amino acids isoleucine and phenylserine, this peptide contained N-desmethyldolaisoleuine, O-desmethyldolaproine, and α-guanidino serine, three residues that have not previously been reported in a natural product. The absolute configurations of the constituent amino/guanidino acids were determined by chemical degradation and derivatization, followed by HPLC and LC-MS comparison with authentic standards. Gymnangiamide (1) was moderately cytotoxic against a number of human tumor cell lines in vitro.