914618-75-0Relevant academic research and scientific papers
INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME
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, (2008/06/13)
A compound of formula (I) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating non-insulin dependent type 2 diabetes, ins
Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Yeh, Vince S.C.,Kurukulasuriya, Ravi,Madar, David,Patel, Jyoti R.,Fung, Steven,Monzon, Katina,Chiou, William,Wang, Jiahong,Jacobson, Peer,Sham, Hing L.,Link
, p. 5408 - 5413 (2007/10/03)
A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and
