914636-84-3

Usage

Properties

Nitrile derivative with a substituted benzene ring containing bromine, chlorine, and amino groups
Used in pharmaceutical and agrochemical industries as an intermediate for synthesis of various organic molecules and active pharmaceutical ingredients
Utilized in research and development for creation of new drugs and agrochemicals
Potential applications in material science and chemical synthesis due to unique chemical properties and reactivity

Usage

Intermediate for synthesis in pharmaceutical and agrochemical industries

Applications

Research and development, material science, chemical synthesis

Upstream product

• 873-38-1 4-chloro-2-bromoaniline 
• 106-47-8 4-chloro-aniline 
• 874-17-9 4-chloro-2,6-dibromoaniline 
• 5922-60-1 2-amino-5-chlorobenzonitrile 

Downstream Products

• 304854-55-5 3-bromo-5-chlorobenzenenitrile 
• 1312923-94-6 3-(2-(6-methylpyridin-2-yl)ethynyl)-5-chlorobenzonitrile 
• 1312923-98-0 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-chlorobenzonitrile 
• 41198-02-1 2-amino-3-bromo-5-chlorobenzoic acid 

Relevant academic research and scientific papers

A PROCESS FOR THE SYNTHESIS ANTHRANILIC DIAMIDE COMPOUNDS AND INTERMEDIATES THEREOF

The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), wherein, R1, R2, R3a, R3b, R3c, R4, R5, R6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va).

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.