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CAS

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914656-05-6

Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 914656-05-6 Structure

  • Basic information

    1. Product Name: Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate
    2. Synonyms: Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate
    3. CAS NO:914656-05-6
    4. Molecular Formula:
    5. Molecular Weight: 520.382
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 914656-05-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate(914656-05-6)
    11. EPA Substance Registry System: Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate(914656-05-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 914656-05-6(Hazardous Substances Data)

914656-05-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 914656-05-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,6,5 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 914656-05:
(8*9)+(7*1)+(6*4)+(5*6)+(4*5)+(3*6)+(2*0)+(1*5)=176
176 % 10 = 6
So 914656-05-6 is a valid CAS Registry Number.

914656-05-6Downstream Products

914656-05-6Relevant articles and documents

Quinoline derivatives as neurokinin receptor antagonists

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Page/Page column 54, (2009/04/24)

The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R1, R2, R3, R4, R5, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II

Elliott, Jason M.,Carling, Robert W.,Chicchi, Gary G.,Crawforth, James,Hutson, Peter H.,Jones, A. Brian,Kelly, Sarah,Marwood, Rose,Meneses-Lorente, Georgina,Mezzogori, Elena,Murray, Fraser,Rigby, Michael,Royo, Inmaculada,Russell, Michael G.N.,Shaw, Duncan,Sohal, Bindi,Tsao, Kwei Lan,Williams, Brian

, p. 5752 - 5756 (2007/10/03)

Introduction of selected amine containing side chains into the 3-position of N′,2-diphenylquinoline-4-carbohydrazide based NK3 antagonists abolishes unwanted hPXR activation. Introduction of a fluorine at the 8-position is necessary to minimize unwanted hIKr affinity and a piperazine N-tert-butyl group is necessary for metabolic stability. The lead compound (8m) occupies receptors within the CNS following oral dosing (Occ90 7 mg/kg po; plasma Occ90 0.4 μM) and has good selectivity and excellent PK properties.

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