914672-48-3Relevant academic research and scientific papers
3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase
Hendricks, Robert T.,Spencer, Stacey R.,Blake, James F.,Fell, Jay B.,Fischer, John P.,Stengel, Peter J.,Leveque, Vincent J.P.,LePogam, Sophie,Rajyaguru, Sonal,Najera, Isabel,Josey, John A.,Swallow, Steven
scheme or table, p. 410 - 414 (2011/03/18)
Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.
Heterocyclic antiviral compounds
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Page/Page column 17, (2010/11/24)
Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and syn
