91475-01-3Relevant articles and documents
BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF
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, (2013/09/12)
The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvar
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide
Hasuda, Tomoyo,Hitotsuyanagi, Yukio,Shinada, Mitsuyuki,Takeya, Koichi
, p. 2757 - 2759 (2012/05/31)
A reduced peptide bond analogue of RA-VII, [Tyr-5-Ψ(CH 2NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by co
SYNTHESIS OF CYCLO-N-METHYL-L-TYR-N-METHYL-L-TYR-D-ALA-L-ALA-O,N-DIMETHYL-L-TYR-L-ALA, A CYCLIC HEXAPEPTIDE RELATED TO THE ANTITUMOR AGENT DEOXYBOUVARDIN
Bates, Robert B.,Gin, Susan L.,Hassen, Mark A.,Hruby, Victor J.,Janda, Kim D.,et al.
, p. 785 - 790 (2007/10/02)
A synthesis of the title cyclic hexapeptide is described.Its lack of antitumor activity shows that the 14-membered ring of deoxybouvardin is needed for activity.Efforts to oxidatively its phenolic groups failed to give deoxybouvardin.