91475-00-2Relevant academic research and scientific papers
BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF
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, (2013/09/12)
The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvar
Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-Containing Analogues of RA-VII, an Antitumor Bicyclic Hexapeptide from Rubia Plants
Hitotsuyanagi, Yukio,Hasuda, Tomoyo,Aihara, Takayuki,Ishikawa, Hiroshi,Yamaguchi, Kentaro,Itokawa, Hideji,Takeya, Koichi
, p. 1481 - 1486 (2007/10/03)
Three analogues of RA-VII (1), an antitumor bicyclic hexapeptide from Rubia plants, were synthesized. Three analogues, [Gly-1]RA-VII (4), [Gly-2]RA-VII (5), and [Gly-4]RA-VII (6), in which one of the three alanine residues in 1 was replaced by a glycine r
Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity
Hitotsuyanagi, Yukio,Ishikawa, Hiroshi,Hasuda, Tomoyo,Takeya, Koichi
, p. 935 - 938 (2007/10/03)
A novel antitumor bicyclic hexapeptide RA-XVII was isolated from the roots of Rubia cordifolia. By spectral studies and synthetic approach, its structure was determined to be [D-2-aminobutyric acid-1]deoxybouvardin. Studies on the effect of side chain at
SYNTHESIS OF CYCLO-N-METHYL-L-TYR-N-METHYL-L-TYR-D-ALA-L-ALA-O,N-DIMETHYL-L-TYR-L-ALA, A CYCLIC HEXAPEPTIDE RELATED TO THE ANTITUMOR AGENT DEOXYBOUVARDIN
Bates, Robert B.,Gin, Susan L.,Hassen, Mark A.,Hruby, Victor J.,Janda, Kim D.,et al.
, p. 785 - 790 (2007/10/02)
A synthesis of the title cyclic hexapeptide is described.Its lack of antitumor activity shows that the 14-membered ring of deoxybouvardin is needed for activity.Efforts to oxidatively its phenolic groups failed to give deoxybouvardin.
