951408-28-9Relevant academic research and scientific papers
Novel Approach toward 3,3-Difluoropiperidines from Easily Available Starting Materials and Synthesis of a New Phosphodiesterase Inhibitor
Giacoboni, Jessica,Clausen, Rasmus P.,Marigo, Mauro
supporting information, p. 2803 - 2806 (2016/12/16)
A novel methodology for the synthesis of 3,3-difluoropiperidines has been developed. The target compounds are prepared in three steps using a robust protocol and simple starting materials. The incorporation of the fluorine is achieved by using the cheap and easily available ethyl 2-bromo-2,2-difluoroacetate as building block. Using this methodology, a new potent in vitro phosphodiesterase 2A (PDE2A) inhibitor containing the functionalized fluorinated piperidine scaffold has been prepared.
New entries toward 3,3-difluoropiperidines
Verniest, Guido,Surmont, Riccardo,Van Hende, Eva,Deweweire, Arvid,Deroose, Frederik,Thuring, Jan Willem,De Kimpe, Norbert
, p. 5458 - 5461 (2008/12/21)
(Chemical Equation Presented) Difluoropiperidines attract considerable interest from organic and medicinal chemists, but their synthesis is often problematic. This paper describes a new synthetic pathway toward valuable 3,3-difluoropiperidines starting fr
