914922-89-7Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF MACROCYCLIC KETONE ANALOGS OF HALICHONDRIN B
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, (2019/11/19)
The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.
Process development of halaven: Synthesis of the C14-C35 fragment via iterative nozaki-hiyama-kishi reaction-williamson ether cyclization
Austad, Brian C.,Benayoud, Farid,Calkins, Trevor L.,Campagna, Silvio,Chase, Charles E.,Choi, Hyeong-Wook,Christ, William,Costanzo, Robert,Cutter, James,Endo, Atsushi,Fang, Francis G.,Hu, Yongbo,Lewis, Bryan M.,Lewis, Michael D.,McKenna, Shawn,Noland, Thomas A.,Orr, John D.,Pesant, Marc,Schnaderbeck, Matthew J.,Wilkie, Gordon D.,Abe, Taichi,Asai, Naoki,Asai, Yumi,Kayano, Akio,Kimoto, Yuichi,Komatsu, Yuki,Kubota, Manabu,Kuroda, Hirofumi,Mizuno, Masanori,Nakamura, Taiju,Omae, Takao,Ozeki, Naoki,Suzuki, Taeko,Takigawa, Teiji,Watanabe, Tomohiro,Yoshizawa, Kazuhiro
, p. 327 - 332 (2013/04/10)
Multikilogram manufacturing process of the Halaven C14-C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment. Georg Thieme Verlag Stuttgart - New York.
