91494-87-0Relevant academic research and scientific papers
Phenylpiperazinylalkylamino substituted pyridazinones as potent α1 adrenoceptor antagonists
Barlocco,Cignarella,Dal Piaz,Giovannoni,De Benedetti,Fanelli,Montesano,Poggesi,Leonardi
, p. 2403 - 2410 (2007/10/03)
QSAR models have been used for designing a series of compounds characterized by a N-phenylpiperazinylalkylamino moiety linked to substituted pyridazinones, which have been synthesized. Measurements of the binding affinities of the new compounds toward the
4-Bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2- naphthalenecarboxamides: Selective dopamine D3 receptor partial agonists
Glase, Shelly A.,Akunne, Hyacinth C.,Heffner, Thomas G.,Johnson, Stephen J.,Kesten, Suzanne R.,Mackenzie, Robert G.,Manley, Peter J.,Pugsley, Thomas A.,Wright, Jon L.,Wise, Lawrence D.
, p. 1361 - 1366 (2007/10/03)
A series of 4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2- naphthalenecarboxamide dopamine (DA) D3 receptor agonists has been identified. These compounds were found to be selective for DA D3 over D2 receptors and were shown to be partial to full agonists as measured by stimulation of mitogenesis in D3-transfected CHO p-5 cells.
