91495-75-9Relevant academic research and scientific papers
5-MEMBERED HETEROARYL CARBOXAMIDE COMPOUNDS FOR TREATMENT OF HBV
-
, (2020/05/28)
The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.
New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3
Stefane, Bogdan,Brozic, Petra,Vehovc, Matej,Rizner, Tea Lanisnik,Gobec, Stanislav
experimental part, p. 2563 - 2571 (2009/10/17)
A series of cyclopentane derivatives was synthesized and evaluated for inhibition of the steroid metabolizing enzymes AKR1C1 and AKR1C3. Selective inhibitors that are active in the low micromolar range were identified. These compounds represent promising starting points in the development of new anticancer agents for the treatment of hormone-dependent forms of cancer and other diseases where AKR1C1 and AKR1C3 are involved.
Oxidative ring contraction of cycloalkanones: A facile metrod for synthesis of medium ring cycloalkanecarboxylic acids
Giurg, Miroslaw,Mlochowski, Jacek
, p. 2281 - 2291 (2007/10/03)
Cycloalkanones (1) oxidized with 30% hydrogen peroxide in the presence of poly(bisanthracenyl) diselenide (5b) as catalyst, produce cycloalkanecarboxylic acids (2) having one carbon atom less in the ring that the substrate. Although preparative yield of acids 2 does not exceed 60% the reaction can be applied as a simple way for synthesis of cycloalkanecarboxylic acids with five to seven-membered ring.
