91497-97-1Relevant academic research and scientific papers
Diversion of a thioglycoligase for the synthesis of 1-: O -acyl arabinofuranoses
Pavic, Quentin,Tranchimand, Sylvain,Lemiègre, Lo?c,Legentil, Laurent
, p. 5550 - 5553 (2018)
An arabinofuranosylhydrolase from the GH51 family was transformed into an acyl transferase by mutation of the catalytic acid/base amino acid. The resulting enzyme was able to transfer carboxylic acid onto the anomeric position of arabinose with complete chemo- and stereoselectivity. A wide range of acyl α-l-arabinofuranoses was obtained with yields ranging from 25 to 83%. Using this method, ibuprofen and N-Boc phenylalanine were successfully transformed into their corresponding acyl conjugates, expanding the scope of the reaction to drugs and amino acids.
