915006-48-3Relevant academic research and scientific papers
Practical one-pot preparation of magnesium Di(hetero)aryl- and magnesium dialkenylboronates for Suzuki-Miyaura cross-coupling reactions
Haag, Benjamin A.,Saemann, Christoph,Jana, Anukul,Knochel, Paul
supporting information; experimental part, p. 7290 - 7294 (2011/09/16)
Mg for B: An atom-economical one-pot synthesis by direct magnesium insertion in the presence of B(OBu)3 and LiCl allows a broad range of functionalized (hetero)aryl and alkenyl bromides to be converted into magnesium diorganoboronates 2, which
Ligand-free and heterogeneous palladium on carbon-catalyzed hetero-suzuki-miyaura cross-coupling
Kitamura, Yoshiaki,Sako, Satoko,Tsutsui, Azusa,Monguchi, Yasunari,Maegawa, Tomohiro,Kitade, Yukio,Sajiki, Hironao
experimental part, p. 718 - 730 (2010/06/16)
A ligand-free and heterogeneous palladium on carbon (Pd/C)-catalyzed hetero-SuzukiMiyaura coupling reaction has been developed. The protocol enables the construction of both heterocyclic-alicyclic and heterocyclic-heterocyclic biaryl derivatives in good to excellent yields. Furthermore, Pd/C could be reused. The time-course study clarified that palladium was leached into the reaction media as the reaction proceeded and then completely deposited on the carbon support.
C-FMS KINASE INHIBITORS
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Page/Page column 106, (2008/06/13)
The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
