915030-00-1

Upstream product

• 54147-04-5 5-amino-1-methyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1188383-78-9 cis-2-(bicyclo[3.1.0]hexan-3-yl)-1-(4-chlorophenyl)-9-methyl-1H-purin-6(9H)-one 

Relevant academic research and scientific papers

SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES

Substituted aryl pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES

Cis-cyclohexyl substituted pyrimidinone derivatives are provided, of Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful

HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES

Haloalkyl-substituted pyrimidinone derivatives are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).