54147-04-5

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 74-89-5 methylamine 
• 32683-02-6 ethyl-2-aminocyano acetate 
• 72809-03-1 ethyl 2,3-diamino propionate 
• 89765-51-5 5-amino-1-methyl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester 
• 52868-72-1 5-amino-2-methylamino-thiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 915030-30-7 3-methyl-5-(2,4,6-trifluorobenzyl)imidazo[4,5-d][1,3]oxazin-7(3H)-one 
• 915030-31-8 N-(5-chloro-1,3-thiazol-2-yl)-1-methyl-5-{[(2,4,6-trifluorophenyl)acetyl]amino}-1H-imidazole-4-carboxamide 
• 1188383-78-9 cis-2-(bicyclo[3.1.0]hexan-3-yl)-1-(4-chlorophenyl)-9-methyl-1H-purin-6(9H)-one 
• 911064-46-5 1-(4-chlorophenyl)-9-methyl-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one hydrochloride 
• 852981-43-2 1-(4-fluorophenyl)-9-methyl-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one 
• 915030-00-1 5-amino-N-(4-chlorophenyl)-1-methyl-1H-imidazole-4-carboxamide 
• 915030-29-4 ethyl 1-methyl-5-{[(2,4,6-trifluorophenyl)acetyl]amino}-1H-imidazole-4-carboxylate 
• 852854-23-0 ethyl 5-({[(4-chlorophenyl)amino]carbonothioyl}amino)-1-methyl-1H-imidazole-4-carboxylate 
• 121845-41-8 ethyl 5-<(2-amino-4-fluorophenyl)amino>-1-methyl-1H-imidazole-4-carboxylate 
• 41507-56-6 N¹-methyl-4-ethoxycarbonylimidazole 
• 121845-34-9 ethyl 4-<(4-fluoro-2-nitrophenyl)amino>-3-methylimidazole-5-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES

Substituted aryl pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

2-PHENOXY PYRIMIDINONE ANALOGUES

2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment

HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES

Haloalkyl-substituted pyrimidinone derivatives are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful

CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES

Cis-cyclohexyl substituted pyrimidinone derivatives are provided, of Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).

2,3-SUBSTITUTED FUSED PYRIMIDIN-4(3H)-ONES AS VR1 ANTAGONISTS

A compound of formula (I), wherein W is formula (1); A is a benzene ring, a fêve-membered heteroaromatic ring containing 1, 2 or 3 heteroatoms independently chosen from O, N and S, providing that no more than one O or S atom is present, or a six- membered

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I) which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VRl, also known as TRPVl).

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).

Angiotensin II receptor antagonists

Compounds are disclosed having the formula: STR1 wherein the substituents are defined herein. The compounds of the invention are angiotensin II receptor antagonists.