915033-10-2Relevant academic research and scientific papers
Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups - Precursors to a variety of α-CF3-α-amino acid derivatives
Skarpos, Hanna,Vorob'eva, Daria V.,Osipov, Sergey N.,Odinets, Irina L.,Breuer, Eli,Roeschenthaler, Gerd-Volker
, p. 3669 - 3674 (2006)
Convenient routes to methyl 2-oxalylimino- and 2-(phosphonoformimido)-3,3,3-trifluoropropanoates have been elaborated, based on the reaction of methyl trifluoropyruvate with ethyl oxamate or diethyl carbamoylphosphonate, respectively, followed by dehydration. The compounds obtained are useful synthetic intermediates toward a variety of novel 3,3,3-trifluoroalanine derivatives that are potential drug candidates. The Royal Society of Chemistry 2006.
