915068-34-7

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 98140-95-5 2-azido-2-methylpropanoic acid ethyl ester 
• 603-35-0 triphenylphosphine 

Downstream Products

• 915068-35-8 N-(1-ethoxycarbonyl-1-methylethyl)-N'-phenylcarbodiimide 
• 622-16-2 1,3-Diphenylcarbodiimide 
• 918525-93-6 C₁₃H₁₉N₃O₂S 

Relevant academic research and scientific papers

Iodocyclization of 3-alkynyl- and 3-allenyl-2-(substituted amino)-1-imidazolin-4-ones

The iodocyclization of 3-alkynyl-2-(substituted amino)-1-imidazolin-4-ones proceeded in regio- and stereo-selective manner to give bicyclic guanidines, imidazo[1,2-a]imidazole and/or imidazo[1,2-a]pyrimidine. The regiochemistry and reactivity of the cyclization were interpretable by the PM3 MO calculations of the iodonium ion intermediates.

New facile synthesis of 3,5-dihydro-6H-imidazo[1,2-b]-1,2,4-triazol-6-ones by an iminophosphorane-mediated annulation

Iminophosphorane 1 reacted with an aromatic isocyanate to unexpectedly give a mixture of carbodiimides 2, 3 and 4 through both the normal and the abnormal aza-Wittig reactions. 3-Aminoimidazolone 10 was obtained from the reaction of hydrazine hydrate with carbodiimide 2. Reaction of 10 with triphenyphosphane, hexachloroethane and triethylamine produced iminophosphorane 11 in good yield. A tandem aza-Wittig reaction of iminophosphorane 11 with isocyanate or CS 2 generated 3,5-dihydro-6H-imidazo[1,2-b]-1,2,4-triazol-6-ones 13 or 15 in satisfactory yield. Carbodiimides 18, obtained from normal aza-Wittig reactions of vinyl iminophosphorane 17 with aromatic isocyanates, reacted with hydrazine to give 2-arylamino-3-amino-4H-imidazol-4-ones 20. One-pot reactions of 2-arylamino-3-amino-4H-imidazol-4-ones 20 with isocyanates (or acyl chlorides), triphenyphosphane, hexachloroethane and triethylamine produced 3,5-dihydro-6H-imidazo[1,2-b]-1,2,4-triazol-6-ones 22 (or 23) in good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Facile synthesis of 2-alkylthio-5,5-dimethyl-4H-imidazol-4-ones

The isothiocyanate 3, obtained from aza-Wittig reaction of iminophosphorane 2 with CS2, reacts with phenylhydrazine to give thiosemicarbazide 4. Reactions of 4 with alkyl halides in the presence of K2CO 3 directly provided

A facile and regio- and stereo-selective preparation of bicyclic guanidines by iodocyclization of 3-(alk-2-enyl)-2-(substituted amino)-1-imidazolin-4-ones

The iodocyclization of 3-(alk-2-enyl)-2-(substituted amino)-1-imidazolin-4-ones proceeded in regio- and stereo-selective manners to give bicyclic guanidines, imidazo[1,2-a]imidazole and/or imidazo[1,2-a]pyrimidine, in good yields. The regiochemistry of th