915068-35-8Relevant academic research and scientific papers
New facile synthesis of 3,5-dihydro-6H-imidazo[1,2-b]-1,2,4-triazol-6-ones by an iminophosphorane-mediated annulation
Yuan, Ju-Zhen,Fu, Bo-Qiao,Ding, Ming-Wu,Yang, Guang-Fu
, p. 4170 - 4176 (2007/10/03)
Iminophosphorane 1 reacted with an aromatic isocyanate to unexpectedly give a mixture of carbodiimides 2, 3 and 4 through both the normal and the abnormal aza-Wittig reactions. 3-Aminoimidazolone 10 was obtained from the reaction of hydrazine hydrate with carbodiimide 2. Reaction of 10 with triphenyphosphane, hexachloroethane and triethylamine produced iminophosphorane 11 in good yield. A tandem aza-Wittig reaction of iminophosphorane 11 with isocyanate or CS 2 generated 3,5-dihydro-6H-imidazo[1,2-b]-1,2,4-triazol-6-ones 13 or 15 in satisfactory yield. Carbodiimides 18, obtained from normal aza-Wittig reactions of vinyl iminophosphorane 17 with aromatic isocyanates, reacted with hydrazine to give 2-arylamino-3-amino-4H-imidazol-4-ones 20. One-pot reactions of 2-arylamino-3-amino-4H-imidazol-4-ones 20 with isocyanates (or acyl chlorides), triphenyphosphane, hexachloroethane and triethylamine produced 3,5-dihydro-6H-imidazo[1,2-b]-1,2,4-triazol-6-ones 22 (or 23) in good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
A facile and regio- and stereo-selective preparation of bicyclic guanidines by iodocyclization of 3-(alk-2-enyl)-2-(substituted amino)-1-imidazolin-4-ones
Watanabe,Okada,Teshima,Noguchi,Kakehi
, p. 2827 - 2838 (2007/10/03)
The iodocyclization of 3-(alk-2-enyl)-2-(substituted amino)-1-imidazolin-4-ones proceeded in regio- and stereo-selective manners to give bicyclic guanidines, imidazo[1,2-a]imidazole and/or imidazo[1,2-a]pyrimidine, in good yields. The regiochemistry of th
