915087-34-2Relevant academic research and scientific papers
MODULATORS OF RESISTANT ANDROGEN RECEPTOR
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Paragraph 00219; 00220, (2014/05/24)
The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making and using the same.
Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)
Jung, Michael E.,Ouk, Samedy,Yoo, Dongwon,Sawyers, Charles L.,Chen, Charlie,Tran, Chris,Wongvipat, John
experimental part, p. 2779 - 2796 (2010/09/05)
A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.
Diarylthiohydantoin compounds
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Page/Page column 7, (2008/06/13)
The present invention relates to diarylthiohydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
DIARYLHYDANTOIN COMPOUNDS
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Page/Page column 80, (2008/06/13)
The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for syntheszing them and using them in the treatment of hormone refractory prostate cancer.
