915092-85-2

Usage

Chemical Properties

White Solid

Upstream product

• 134523-03-8 lipitor 
• 106-95-6 allyl bromide 
• 107-18-6 allyl alcohol 

Downstream Products

• 1353049-83-8 allyl 2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate 
• 1353050-28-8 (3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-07-3 C₄₉H₆₇FN₄O₁₂Si₂ 
• 1353050-29-9 (3R,5R)-((R)-2,3-bis(nitrooxy)propyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-06-2 C₄₈H₆₅FN₄O₁₂Si₂ 
• 1353050-19-7 (3R,5R)-((S)-3,4-bis (nitrooxy)butyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-04-0 C₄₉H₆₇FN₄O₁₂Si₂ 
• 1353050-30-2 (3R,5R)-((R)-2,6-bis(nitrooxy)hexyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-02-8 C₅₁H₇₁FN₄O₁₂Si₂ 
• 1353050-21-1 (3R,5R)-((S)-2,6-bis(nitrooxy)hexyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-00-6 C₅₁H₇₁FN₄O₁₂Si₂ 
• 1353050-22-2 (3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353049-98-5 C₅₁H₇₁FN₄O₁₃Si₂ 
• 1353050-23-3 (3R,5R)-((S)-1-((R)-2,3-bis(nitrooxy)propyl)pyrrolidin-2-yl)methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 

Relevant academic research and scientific papers

Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases

We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results sugges

STATIN DERIVATIVES

Dinitrate statins having improved pharmacological activity are described. They can be employed for treating and/or preventing several diseases, in particular acute coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.