915092-85-2

Basic information

• Product Name: Atorvastatin Ellyl Ester
• Synonyms: Atorvastatin Ellyl Ester;Atorvastatin Allyl Ester;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 2-Propen-1-yl Ester;2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 2-Propenyl Ester
• CAS NO: 915092-85-2
• Molecular Formula: C₃₆H₃₉FN₂O₅
• Molecular Weight: 598.7036632
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals
• Mol File: 915092-85-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Atorvastatin Ellyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Atorvastatin Ellyl Ester(915092-85-2)
• EPA Substance Registry System: Atorvastatin Ellyl Ester(915092-85-2)

Safety Data

• Hazardous Substances Data: 915092-85-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 134523-03-8 lipitor 
• 107-18-6 allyl alcohol 
• 106-95-6 allyl bromide 

Downstream Products

• 1353049-83-8 allyl 2-((6R,8R)-8-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2,4,4-tetraisopropyl-1,3,5,2,4-trioxadisilocan-6-yl)acetate 
• 1353050-28-8 (3R,5R)-((R)-3,4-bis (nitrooxy)butyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-07-3 C₄₉H₆₇FN₄O₁₂Si₂ 
• 1353050-29-9 (3R,5R)-((R)-2,3-bis(nitrooxy)propyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-06-2 C₄₈H₆₅FN₄O₁₂Si₂ 
• 1353050-19-7 (3R,5R)-((S)-3,4-bis (nitrooxy)butyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-04-0 C₄₉H₆₇FN₄O₁₂Si₂ 
• 1353050-30-2 (3R,5R)-((R)-2,6-bis(nitrooxy)hexyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-02-8 C₅₁H₇₁FN₄O₁₂Si₂ 
• 1353050-21-1 (3R,5R)-((S)-2,6-bis(nitrooxy)hexyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353050-00-6 C₅₁H₇₁FN₄O₁₂Si₂ 
• 1353050-22-2 (3R,5R)-((S)-2-(nitrooxy)-3-(3-(nitrooxy)propoxy)propyl)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 
• 1353049-98-5 C₅₁H₇₁FN₄O₁₃Si₂ 
• 1353050-23-3 (3R,5R)-((S)-1-((R)-2,3-bis(nitrooxy)propyl)pyrrolidin-2-yl)methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate 

Relevant articles and documents

Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases

We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results sugges