915093-13-9Relevant academic research and scientific papers
Indium-promoted reformatsky reaction: A straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds
Poisson, Thomas,Belhomme, Marie-Charlotte,Pannecoucke, Xavier
, p. 9277 - 9285,9 (2012/12/12)
A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines,
Indium-promoted reformatsky reaction: A straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds
Poisson, Thomas,Belhomme, Marie-Charlotte,Pannecoucke, Xavier
, p. 9277 - 9285 (2013/01/15)
A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines,
Ethyl difluoro(trimethylsilyl)acetate and difluoro(trimethylsilyl) acetamides - Precursors of 3,3-difluoroazetidinones
Bordeau, Michel,Frebault, Frederic,Gobet, Mallory,Picard, Jean-Paul
, p. 4147 - 4154 (2007/10/03)
Difluoro(trimethylsilyl)acetamides 7 have been prepared from chlorodifluoroacetamides 5 by electrochemical silylation. When condensed with carbonyl compounds, they were shown to be precursors of 2,2-difluoro-3- hydroxyacetamides 8. N-(p-Methoxyphenyl)-2,2-difluoro-3-hydroxy-4- methylvaleramide (8a) has been converted into the correspending 3,3-difluoroazetidinone 9a. This new route to 3,3-difluoroazetidinones is shown to be an alternative to the one utilizing the condensation of ethyl difluoro(trimethylsilyl)acetate with imines. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
The simple and selective synthesis of 3-amino-2,2-difluorocarboxylic esters and difluoro-β-lactams using ethyl bromodifluoroacetate in the presence of rhodium catalyst
Sato, Kazuyuki,Tarui, Atsushi,Matsuda, Seiji,Omote, Masaaki,Ando, Akira,Kumadaki, Itsumaro
, p. 7679 - 7681 (2007/10/03)
Treatment of imines (5) with ethyl bromodifluoroacetate (1) and Et 2Zn in the presence of RhCl(PPh3)3 in anhydrous medium gave difluoro-β-lactams (7) in good to excellent yields, while 3-amino-2,2-difluorocarboxylic esters (6) were obtained in good yields by adding MgSO4·7H2O to the reaction medium.
