915094-63-2

Upstream product

• 2788-84-3 (S)-serine methyl ester 
• 104499-27-6 (S)-2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 1095976-49-0 C₂₁H₃₂N₂O₆Si 
• 915094-66-5 2-((S)-1-Benzyloxycarbonylamino-2-hydroxy-ethyl)-oxazole-4-carboxylic acid methyl ester 
• 915094-65-4 2-[(S)-1-benzyloxycarbonylamino-2-(tert-butyldimethylsilanyloxy)ethyl]oxazole-4-carboxylic acid 
• 915094-69-8 C₂₆H₃₀N₄O₈Si 
• 915094-68-7 2''-[(S)-1-benzyloxycarbonylamino-2-(tert-butyldimethylsilanyloxy)ethyl][2,4';2',4'']teroxazole-4-carboxylic acid methyl ester 
• 915094-67-6 2-[(S)-1-({2-[(S)-1-benzyloxycarbonylamino-2-(tert-butyldimethylsilanyloxy)ethyl]oxazole-4-carbonyl}amino)-2-hydroxyethyl]oxazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatin

A convergent, complementary, synthetic approach to the contiguously linked tris-oxazole units 10, 11 and 12 in telomestatin (1) and YM-216391 (2) is described. The route involves coupling reactions between oxazole 4-carboxylic acids, viz16a, 16c, 16d and

Design and synthesis of telomestatin derivatives and their inhibitory activity of telomerase

Telomestatin derivatives of 2a-2c, which have macrocyclic bisamide structure, were designed and synthesized. One of these compounds (2a) showed inhibitory activity of telomerase with an 1C50 of 2μM.