915107-47-0Relevant articles and documents
Synthesis method of imidacloprid metabolite 5-hydroxyimidacloprid
-
, (2021/07/28)
The invention discloses a synthesis method of an imidacloprid metabolite 5-hydroxyimidacloprid, and belongs to the field of medicine synthesis. According to the synthesis method, methyl 5-hydroxynicotinate is used as a raw material, synthesis of the imidacloprid metabolite 5-hydroxylimidacloprid is achieved for the first time through six-step reaction, an optimal synthesis route and reaction conditions are screened out through a large number of experiments, the purity of the prepared target product can reach 99% or above, and the target product does not contain raw material medicine imidacloprid can be used for research on pharmacokinetics, raw material medicine impurity identification, environment control and protection and the like, provides a sample for impurity identification of imidacloprid, metabolic mechanism research, influence on the environment after medicine use, how to carry out corresponding protection and the like, and has important application value.
HETEROCYCLIC DERIVATES
-
Page/Page column 91, (2014/12/12)
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B,W, X, Y and Z are as defined herein.