91525-94-9Relevant academic research and scientific papers
ASYMMETRIC SYNTHESIS VIA CHIRAL SILICON REAGENTS. CHIRAL α-HYDROXYALKYL ANION EQUIVALENTS FROM VINYLSILANES CONTAINING OPTICALLY ACTIVE AMINO OR ALKOXY GROUPS ON SILICON
Tamao, Kohei,Kanatani, Ryuichiro,Kumada, Makoto
, p. 1913 - 1916 (2007/10/02)
Chiral vinylsilanes containing optically active functional groups on silicon have been used as precursors for chiral α-hydroxyalkyl anion equivalents via a sequence of addition of n-butyllithium, coupling with organic halides, and oxidative cleavage of the silicon-carbon bond, to give optically active alcohols of up to 60percent ee.
