915287-92-2Relevant academic research and scientific papers
Synthesis of (R)- and (S)-[O-methyl-11C]N-[2-[3-(2-cyano- phenoxy) -2-hydroxy-propylamino]-ethyl]-N′-(4-methoxy-phenyl)-urea as candidate high affinity β1-adrenoceptor PET radioligands
Wagner, Stefan,Law, Marilyn P.,Riemann, Burkhard,Pike, Victor W.,Breyholz, Hans-Joerg,Hoeltke, Carsten,Faust, Andreas,Schober, Otmar,Schaefers, Michael,Kopka, Klaus
, p. 721 - 733 (2005)
Molecular imaging and quantification of myocardial β1- adrenoceptor (AR) rather than total β-AR density is of great clinical interest since cardiac biopsy studies suggest that myocardial β1-AR density is reduced in patients with chro
Synthesis and cardiac imaging of 18F-ligands selective for β1-adrenoreceptors
Radeke, Heike S.,Purohit, Ajay,Harris, Thomas D.,Hanson, Kelley,Jones, Reinaldo,Hu, Carol,Yalamanchili, Padmaja,Hayes, Megan,Yu, Ming,Guaraldi, Mary,Kagan, Mikhail,Azure, Michael,Cdebaca, Michael,Robinson, Simon,Casebier, David
, p. 650 - 655 (2011/11/05)
A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/ β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribution studies demonstrated uptake of each radiotracers from the blood pool into the myocardium (0.48-0.62% ID/g), lung (0.63-0.97% ID/g), and liver (1.03-1.14% ID/g). Dynamic μPET imaging confirmed the in vivo dissection studies.
