915296-86-5

Upstream product

• 915296-85-4 (E)-1-benzyl-4-(2,4-dichlorobenzylidene)pyrrolidine-2,3-dione 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 100-46-9 benzylamine 
• 23583-21-3 ethyl-3-benzylamino propionate 
• 1135991-71-7 1-benzoyl-5-benzyl-2-(2,4-dichlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione 
• 626-34-6 ethyl aminocrotonate 

Downstream Products

• 915296-88-7 6-Benzyl-4-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-methyl-5,6-dihydropyrrolo[3,4-b]pyridin-7-one 
• 1163169-72-9 C₂₂H₁₇Cl₃N₂O 
• 915296-89-8 Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-6H-pyrrolo[3,4-b]pyridine-3-carboxylate 
• 915296-90-1 (6-Benzyl(2,4-dichlorophenyl)-2-methyl-6H-pyrrolo[3,4-b]pyridin-3-yl)methanol 
• 1163182-14-6 C₂₂H₁₇Cl₃N₂ 
• 915296-93-4 (6-Benzyl-4-(2,4-dichlorophenyl)-2-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)methanol 
• 1163203-88-0 C₂₂H₁₉Cl₃N₂ 
• 915296-87-6 Ethyl 6-benzyl-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate 

Relevant academic research and scientific papers

7-Oxopyrrolopyridine-derived DPP4 inhibitors - Mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site

Design, synthesis, and SAR of 7-oxopyrrolopyridine-derived DPP4 inhibitors are described. The preferred stereochemistry of these atropisomeric biaryl analogs has been identified as Sa. Compound (+)-3t, with a Ki against DPP4, DPP8, and DPP9 of 0.37 nM, 2.2, and 5.7 μM, respectively, showed a significant improvement in insulin response after single doses of 3 and 10 μmol/kg in ob/ob mice.

Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods

Compounds are provided having the formula (I) wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases.