915302-83-9

Upstream product

• 100-39-0 benzyl bromide 
• 915302-84-0 (-)-(7S)-7-amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane D-mandelate 
• 915302-80-6 tert-butyl (5-benzyl-7-methyl-4-oxo-5-azaspiro[2.4]hept-7-yl)carbamate 
• 915302-78-2 tert-butyl (7-methyl-4-oxo-5-azaspiro[2.4]hept-7-yl)carbamate 
• 915795-01-6 7-amino-7-methyl-5-azaspiro[2.4]heptan-4-one 
• 915794-99-9 1-(1,2-diamino-1-methylethyl)-1-cyclopropanecarboxylic acid tert-butyl ester 
• 915867-73-1 1-(1,2-diamino-1-methylethyl)-1-cyclopropanecarboxylic acid 
• 915794-98-8 1-(1-amino-1-cyanoethyl)-1-cyclopropanecarboxylic acid tert-butyl ester 
• 102540-66-9 tert-butyl 1-acetylcyclopropane-1-carboxylate 

Downstream Products

• 915302-90-8 (-)-(7S)-7-t-butoxycarbonylamino-7-methyl-5-azaspiro[2.4]heptane 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl- 5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens(1)

Novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)- 2-fluorocyclopropyl]- 8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 2a and 2b were designed and synthesized to obtain potent antibacterial drugs for the treatment of respi

HYDRATE FOR MEDICAL PURPOSES

The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has exc

METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND

Disclosed is a method for commercially producing a spiroaminopyrrolidone derivative as an intermediate for a quinolone antibacterial agent. Specifically disclosed is a method for producing a compound represented by the formula (2) below wherein a compound

Tri-, tetra-substituted-3-aminopyrrolidine derivative

A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria, and which are also highly safe are provided. The compound provided is represented by following formula (I): wherein R1 and R2 represent hydrogen atom, or the like; R3 represents an alkyl group containing 1 to 6 carbon atoms, or the like; R4 and R5 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like, with the proviso that R4 and R5 do not simultaneously represent hydrogen atom; or the substituents R4 and R5 together represent (a) a 3- to 6-membered cyclic structure including the carbon atom shared by R4 and R5 to form a spirocyclic structure with the pyrrolidine ring; R6 and R7 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like; R8 represents a halogen-substituted alkyl group containing 1 to 6 carbon atoms, or the like; X1 represents hydrogen atom or a halogen atom; A represents nitrogen atom or a moiety represented by formula (II):