915307-16-3

Upstream product

• 915307-15-2 (3aS,9aR,10S,10aS)-2,2-dimethylhexahydro-4H-[1,3]dioxolo[4,5]pyrido[1,2-c][1,3]oxazin-10-ol 
• 100-39-0 benzyl bromide 
• 915307-12-9 (4R,5S)-5-Ethynyl-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 917354-57-5 (3aS,8aR,9aR)-2,2-Dimethyl-tetrahydro-1,3,6-trioxa-4a-aza-cyclopenta[b]naphthalen-9-one 
• 915307-14-1 (3aS,9aR,10S,10aR)-10-(hydroxymethyl)-2,2-dimethylhydro-4H-[1,3]dioxolo[4,5]pyrido[1,2-c][1,3]oxazin-10-ol 
• 915307-11-8 3-{[(4S,5S)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-4-(trimethylsilyl)-1,3-oxazinane 
• 915307-13-0 3-{[(4S,5S)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl]methylamino}-3-(trimethylsilyl)propan-1-ol 
• 360562-50-1 1,2-Dideoxy-3,4-O-(1-methylethylidene)-L-threo-pent-1-ynitol 

Downstream Products

• 916451-48-4 (3S,4R,5S,6R)-3,4,5-Tris-benzyloxy-1-aza-bicyclo[4.2.0]octan-8-one 
• 916451-46-2 (4aR,5S,6R,7S)-5,6,7-Tris-benzyloxy-hexahydro-pyrido[1,2-c][1,3]oxazine 
• 916451-47-3 (2R,3S,4R,5S)-3,4,5-Tris-benzyloxy-2-carboxymethyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Convergent approach toward the synthesis of the stereoisomers of C-6 homologues of 1-deoxynojirimycin and their analogues: Evaluation as specific glycosidase inhibitors

A new and stereoselective strategy is developed to synthesize an appropriate template 9 to obtain C-6 homologues of 1-deoxyazasugars such as 1-deoxy-D-galactohomonojirimycin (S), 1-deoxy-4-hydroxy-methyl-D- glucohomonojirimycin (6), and their enantiomers. The template 9 is also used to obtain neutral nonbasic pseudo-glyconolactam (8), C-4 amino, and methyl analogues of 1-deoxy-homonojirimycin as new analogues of 1-deoxyhomoazasugars. Compound 5 is found to be a potent and specific inhibitor to α-galactosidase (Ki = 1.7 μM). Similarly compounds 6 (K i = 28 μM), ent-5 (Ki = 129 μM), and ent-6 (K i = 12 μM) exhibited specific inhibition of β-glucosidase.

A β-lactam-azasugar hybrid as a competitive potent galactosidase inhibitor

A β-lactam-azasugar hybrid (polyhydroxylated carbacephem) has been designed and synthesized as a potent glycosidase inhibitor.