91534-30-4

Upstream product

• 85960-31-2 ethyl 4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate 
• 91534-26-8 ethyl 2'-((N,N-dimethylamino)methyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate 
• 91534-28-0 ethyl 2'-(cyanomethyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate 
• 2396-84-1 (2E,4E)-ethyl hexa-2,4-dienoate 
• 85960-32-3 2-Allyl-1'-benzenesulfonyl-4'-methyl-1H,1'H-[3,3']bipyrrolyl-4-carboxylic acid ethyl ester 
• 107913-92-8 1'-Benzenesulfonyl-2-(2,3-dihydroxy-propyl)-4'-methyl-1H,1'H-[3,3']bipyrrolyl-4-carboxylic acid ethyl ester 
• 85960-30-1 (E)-3-(1-Benzenesulfonyl-4-methyl-1H-pyrrol-3-yl)-acrylic acid ethyl ester 
• 85960-29-8 ethyl (E)-3-(4-methyl-1H-pyrrol-3-yl)acrylate 
• 91534-29-1 ethyl 2'-((methoxycarbonyl)methyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate 
• 107913-93-9 ethyl 2'-(formylmethyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate 

Downstream Products

• 91534-32-6 ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 
• 91534-31-5 1'-Benzenesulfonyl-2-chlorocarbonylmethyl-4'-methyl-1H,1'H-[3,3']bipyrrolyl-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Unprotected Cyclopropapyrroloindole A Portion Using the 3,3'-Bipyrrole Strategy

The total synthesis of the unprotected A portion of the potent cytotoxic agent CC-1065 1 using the 3,3'-bipyrrole strategy is described.Treatment of ethyl sorbate with (p-tolylsulfonyl)methyl isocyanide (TosMIC)/NaH gave the pyrrole 7, which was N'-phenyl

Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Cyclopropapyrroloindole Portion

Using a regioselective Mannich reaction the 3,3'-bipyrrole (4) is converted into the acid chloride (10), which is transformed into the tricyclic phenol (11); selective reduction of (11) using triethylsilane in trifluoroacetic acid gives (12), which is con