91534-32-6

Basic information

• Product Name: ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate
• Synonyms: ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate
• CAS NO: 91534-32-6
• Molecular Weight: 398.439
• Mol File: 91534-32-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate(91534-32-6)
• EPA Substance Registry System: ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate(91534-32-6)

Safety Data

• Hazardous Substances Data: 91534-32-6(Hazardous Substances Data)

Upstream product

• 105805-22-9 ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate 
• 105805-21-8 ethyl (7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)glyoxolate 
• 105805-20-7 7-benzyloxy-4-bromo-3-methyl-1-phenylsulphonyl-1H-indole 
• 105805-18-3 1-azido-2-(5'-benzyloxy-2'-bromophenyl)propan-2-ol 
• 119098-01-0 1-azido-2-(5'-benzyloxy-2'-bromophenyl)propene 
• 105805-17-2 2-(5'-benzyloxy-2'-bromophenyl)-2-methyl-oxirane 
• 105805-16-1 1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone 
• 91534-31-5 1'-Benzenesulfonyl-2-chlorocarbonylmethyl-4'-methyl-1H,1'H-[3,3']bipyrrolyl-4-carboxylic acid ethyl ester 
• 91534-30-4 ethyl 2'-(carboxymethyl)-4-methyl-1-(phenylsulfonyl)-3,3'-bipyrrole-4'-carboxylate 
• 105805-23-0 ethyl 5-benzyloxy-3,6-dihydro-8-methyl-6-phenylsulphonylpyrrolo<3,2-e>indole-1-carboxylate 

Downstream Products

• 91534-37-1 1,2,8,8a-tetrahydro-7-methyl-5-phenylsulphonylcyclopropapyrrolo<3,2-e>indol-4(5H)-one 
• 91534-35-9 3-acetyl-1,2,3,6-tetrahydro-5-hydroxy-1-hydroxymethyl-8-methyl-6-phenylsulphonylpyrrolo<3,2-e>indole 
• 91534-36-0 2-acetyl-1,2,8,8a-tetrahydro-7-methyl-5-(phenylsulfonyl)cyclopropa-pyrrolo<3,2-e>indol-4(5H)-one 
• 91534-34-8 ethyl 1,2,3,6-tetrahydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)-3-acetylbenzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 
• 119098-06-5 2-(4-t-butylbenzoyl)-1,2,8,8a-tetrahydro-7-methyl-5-phenylsulphonylcyclopropapyrrolo<3,2-e>indol-4(5H)-one 
• 104636-99-9 2-(1H-indol-2-ylcarbonyl)-1,2,8,8a-tetrahydro-7-methylcyclopropapyrrolo<3,2-c>indol-4(5H)-one 
• 91534-33-7 6-Benzenesulfonyl-5-hydroxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid ethyl ester 

Relevant articles and documents

Formal Synthesis of the Antitumour Antibiotic CC-1065

A formal total synthesis of the potent antitumour antibiotic CC-1065 (1) is described; both the cyclopropapyrroloindole (2) and the 'dimeric' pyrroloindole (3) are synthesized by routes involving vinyl azide chemistry.The cyclopropapyrroloindole (2) is prepared from 5-benzyloxy-2-bromoacetophenone (Schemes 3-5), the key steps being the formation of both indoles by decomposition of the azides (9) and (13).The dimer (3) is prepared by coupling the monomeric pyrroloindoles (25) and (27), followed by functional group transformations (Scheme 7).

Synthesis of the Left-hand Unit of the Antitumor Agent CC-1065

The cyclopropapyrroloindole (3), the left-hand unit of the antitumour agent CC-1065 (1), has been synthesized from 3-hydroxyacetophenone by a route which involves construction of both pyrrole rings by thermolysis of vinyl azides.