915366-64-2Relevant academic research and scientific papers
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood
Wu, Junjun,Green, Neal,Hotchandani, Rajeev,Hu, Yonghan,Condon, Jeffrey,Huang, Adrian,Kaila, Neelu,Li, Huan-Qiu,Guler, Satenig,Li, Wei,Tam, Steve Y.,Wang, Qin,Pelker, Jeffrey,Marusic, Suzana,Hsu, Sang,Perry Hall,Telliez, Jean-Baptiste,Cui, Junqing,Lin, Lih-Ling
scheme or table, p. 3485 - 3488 (2010/03/03)
Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-α (TNF-α) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-a
