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CAS

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915364-18-0

3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 915364-18-0 Structure

  • Basic information

    1. Product Name: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-
    2. Synonyms: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-;6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile
    3. CAS NO:915364-18-0
    4. Molecular Formula: C16H9Cl2FN4
    5. Molecular Weight: 347.1738632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 915364-18-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 537.1°C at 760 mmHg
    3. Flash Point: 278.7°C
    4. Appearance: /
    5. Density: 1.54g/cm3
    6. Vapor Pressure: 1.31E-11mmHg at 25°C
    7. Refractive Index: 1.719
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 1.56±0.50(Predicted)
    11. CAS DataBase Reference: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-(915364-18-0)
    13. EPA Substance Registry System: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-(915364-18-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 915364-18-0(Hazardous Substances Data)

915364-18-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 915364-18-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,3,6 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 915364-18:
(8*9)+(7*1)+(6*5)+(5*3)+(4*6)+(3*4)+(2*1)+(1*8)=170
170 % 10 = 0
So 915364-18-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H9Cl2FN4/c17-12-5-10(1-2-14(12)19)23-15-8(6-20)7-22-16-11(15)3-9(21)4-13(16)18/h1-5,7H,21H2,(H,22,23)

915364-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Amino-8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-quinolineca rbonitrile

1.2 Other means of identification

Product number -
Other names 4H-1,3-Benzodioxin-6-amine,8-chloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:915364-18-0 SDS

915364-18-0Upstream product

915364-18-0Relevant articles and documents

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor α (TNF-α) production: Selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3- carbonitriles

Green, Neal,Hu, Yonghan,Janz, Kristin,Li, Huan-Qiu,Kaila, Neelu,Guler, Satenig,Thomason, Jennifer,Joseph-McCarthy, Diane,Tam, Steve Y.,Hotchandani, Rajeev,Wu, Junjun,Huang, Adrian,Wang, Qin,Leung, Louis,Pelker, Jefferey,Marusic, Suzana,Hsu, Sang,Telliez, Jean-Baptiste,Hall, J. Perry,Cuozzo, John W.,Lin, Lih-Ling

, p. 4728 - 4745 (2008/03/11)

Tumor progression loci-2 (Tpl2) (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family directly upstream of MEK. Recent studies using Tpl2 knockout mice have indicated an important role for Tpl2 in the lipopolysaccharide (LPS) induced production of

3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same

-

Page/Page column 80; 82, (2008/06/13)

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as

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