915364-18-0

Basic information

• Product Name: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-
• Synonyms: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-;6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile
• CAS NO: 915364-18-0
• Molecular Formula: C₁₆H₉Cl₂FN₄
• Molecular Weight: 347.1738632
• Mol File: 915364-18-0.mol

Chemical Properties

• Boiling Point: 537.1°C at 760 mmHg
• Flash Point: 278.7°C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 1.31E-11mmHg at 25°C
• Refractive Index: 1.719
• PKA: 1.56±0.50(Predicted)
• CAS DataBase Reference: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-(915364-18-0)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 6-aMino-8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-(915364-18-0)

Safety Data

• Hazardous Substances Data: 915364-18-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H9Cl2FN4/c17-12-5-10(1-2-14(12)19)23-15-8(6-20)7-22-16-11(15)3-9(21)4-13(16)18/h1-5,7H,21H2,(H,22,23)

Relevant articles and documents

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor α (TNF-α) production: Selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3- carbonitriles

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3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as