915367-68-9

Basic information

• Product Name: 8-chloro-4-(3-chloro-4-fluoro-anilino)-6-[[1-(4-piperidyl)triazol-4-yl]methylamino]quinoline-3-carbonitrile
• Synonyms: 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[(1-piperidin-4-yltriazol-4-yl)methylamino]quinoline-3-carbonitrile;3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-6-[[[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]Methyl]aMino]-
• CAS NO: 915367-68-9
• Molecular Formula: C₂₄H₂₁Cl₂FN₈
• Molecular Weight: 511.38
• Mol File: 915367-68-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 720.5°C at 760 mmHg
• Flash Point: 389.6°C
• Density: 1.53g/cm³
• Vapor Pressure: 1.3E-20mmHg at 25°C
• Refractive Index: 1.734
• CAS DataBase Reference: 8-chloro-4-(3-chloro-4-fluoro-anilino)-6-[[1-(4-piperidyl)triazol-4-yl]methylamino]quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-4-(3-chloro-4-fluoro-anilino)-6-[[1-(4-piperidyl)triazol-4-yl]methylamino]quinoline-3-carbonitrile(915367-68-9)
• EPA Substance Registry System: 8-chloro-4-(3-chloro-4-fluoro-anilino)-6-[[1-(4-piperidyl)triazol-4-yl]methylamino]quinoline-3-carbonitrile(915367-68-9)

Safety Data

• Hazardous Substances Data: 915367-68-9(Hazardous Substances Data)

Upstream product

• 915364-18-0 6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
• 1175146-83-4 1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carbaldehyde 

Relevant articles and documents

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-α (TNF-α) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-a