915379-45-2Relevant academic research and scientific papers
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: Synthesis and selectivity
Watson, Paul S.,Jiang, Bin,Harrison, Kim,Asakawa, Nao,Welch, Patricia K.,Covington, Maryanne,Stowell, Nicole C.,Wadman, Eric A.,Davies, Paul,Solomon, Kimberly A.,Newton, Robert C.,Trainor, George L.,Friedman, Steven M.,Decicco, Carl P.,Ko, Soo S.
, p. 5695 - 5699 (2006)
Linear unselective CCR3 antagonist leads with IC50 values in the 200 nM range were converted into low nM binding compounds selective at CCR3 by moving the piperidine nitrogen substituent to the carbon at the 2-position of the ring. Substitution
