251107-37-6

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester
• Synonyms: 1-Piperidinecarboxylic acid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester;tert-butyl 4-benzylpiperidine-1-carboxylate
• CAS NO: 251107-37-6
• Molecular Formula: C₁₇H₂₅NO₂
• Molecular Weight: 275.3859
• Mol File: 251107-37-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 370.0±11.0 °C(Predicted)
• Appearance: /
• Density: 1.047±0.06 g/cm3(Predicted)
• PKA: -1.28±0.40(Predicted)
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester(251107-37-6)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester(251107-37-6)

Safety Data

• Hazardous Substances Data: 251107-37-6(Hazardous Substances Data)

Usage

Molecular weight

279.36 g/mol

Appearance

White solid

Stability

Stable under normal conditions

Handling and storage

Easily handled and stored

Main application

Pharmaceutical research (production of drugs and natural products)

Other applications

Production of agrochemicals and other fine chemicals

Use as a reagent

Commonly used in organic synthesis

Derivative of

Piperidine (heterocyclic amine)

Utilization

As a protecting group for amines in peptide synthesis

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 544478-05-9 4-benzyl-N-tritylpiperidine 
• 31252-42-3 4-benzylpyperidine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 145508-94-7 tert-butyl 4-(iodomethyl)piperidine-1-carboxylate 
• 201230-82-2 carbon monoxide 
• 75-65-0 tert-butyl alcohol 
• 100-39-0 benzyl bromide 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 100-59-4 phenylmagnesium chloride 
• 23418-91-9 9-phenyl-9-borabicyclo[3.3.1]nonane 

Downstream Products

• 251107-38-7 tert-butyl 4-benzyl-2-methylpiperidine-1-carboxylate 

Relevant articles and documents

Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki-Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons

We report here a mechanistically distinct approach to achieve Suzuki-Miyaura-type cross-couplings between alkyl iodides and aryl organoborons. This process requires a copper catalyst but, in contrast with previous approaches based on palladium and nickel

Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki-Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.

Single-step conversion of N-benzyl, N-trityl and N-diphenylmethyl amines to t-butyl carbamates using polymethylhydrosiloxane

t-Butyl carbamates were obtained efficiently in high yields from the corresponding N-benzyl, N-trityl and N-diphenylmethyl precursors in a single-step reductive transformation employing polymethylhydrosiloxane and di-t-butyl dicarbonate under Pd(OH)2/C catalysis.