91538-20-4

Basic information

• Product Name: [(E)-Bis-(4-methoxy-phenyl)-methylimino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS NO: 91538-20-4
• Molecular Weight: 437.579
• Mol File: 91538-20-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [(E)-Bis-(4-methoxy-phenyl)-methylimino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(E)-Bis-(4-methoxy-phenyl)-methylimino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester(91538-20-4)
• EPA Substance Registry System: [(E)-Bis-(4-methoxy-phenyl)-methylimino]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester(91538-20-4)

Safety Data

• Hazardous Substances Data: 91538-20-4(Hazardous Substances Data)

Upstream product

• 19293-62-0 p,p'-dimethoxybenzhydrylamine 
• 111969-64-3 L-menthyl glyoxylate monohydrate 
• 26315-61-7 L-menthyl glyoxylate 

Downstream Products

• 91538-22-6 (3S,4S)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4--2-azetidinone 
• 91538-22-6 (3S,4S)-1-(di-p-anisylmethyl)-3-<(S)-1-hydroxyethyl>-4--2-azetidinone 
• 86258-97-1 (3S,4S)-4-carboxy-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-2-azetidinone 
• 144539-96-8 (2S,3S)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-ethyl-4-oxo-azetidine-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 144452-51-7 (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-ethyl-4-oxo-azetidine-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 98759-26-3 (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-4-oxo-3-vinyl-azetidine-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 91538-21-5 (3S,4S)-3-acetyl-1-(di-p-anisylmethyl)-4-(l-menthyloxycarbonyl)-2-azetidinone 
• 91604-28-3 (3R,4R)-3-acetyl-1-(di-p-anisylmethyl)-4-(l-menthyloxycarbonyl)-2-azetidinone 

Relevant articles and documents

Synthetic studies of carbapenem and penem antibiotics. II. Synthesis of 3-acetyl-2-azetidinones by (2 + 2) cycloaddition of diketene and schiff bases

It was found that (2 + 2) cycloaddition reaction of diketene with Schiff bases was effectively promoted by imidazole as a catalyst to afford 3-acetyl-2-azetidinone derivatives 4. As an application of this new method, a practical asymmetric synthesis of 4 and its conversion into (3S,4S)-4-carboxy-1-(di-p-anisylmethyl)-3-[(R)-1-hydroxyethyl]-2-azeti dinone, which is a key intermediate for the synthesis of carbapenem and penem antibiotics, were accomplished.