91538-89-5Relevant academic research and scientific papers
Novel cyclodehydration reaction of hydroxyphenols. An alternative to the Mitsunobu reaction
Procopiou, Panayiotis A.,Brodie, Alastair C.,Deal, Martyn J.,Hayman, David F.,Smith, Gary M.
, p. 2249 - 2256 (2007/10/03)
A mild, efficient and stereospecific intramolecular process for converting hydroxyphenols into benzodioxanes, dihydrobenzopyrans and dihydrobenzofurans via imidate esters is described. The only by-products are N,N-dimethylformamide and triethylamine hydrochloride which are removed by aqueous work-up making this process highly amenable to large scale operation.
