915390-33-9

Upstream product

• 300853-88-7 (3R,4S)-3-(([tert-butyl(dimethyl)silyl]oxy)methyl)-4-phenylpyrrolidine 
• 31140-40-6 methyl 4-[(chlorocarbonyl)oxy]benzoate 
• 915390-22-6 4-(methoxycarbonyl)phenyl (3R,4S)-3-(hydroxymethyl)-4-phenylpyrrolidine-1-carboxylate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 915390-34-0 4-(methoxycarbonyl)phenyl (3R,4S)-3-(azidomethyl)-4-phenylpyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).